Protein Type AA: Causes, Symptoms, And Treatment

It’s important to know details about protein type aa (amyloidosis) including symptoms, causes, and treatments. It’s important to treat the main cause of the inflammation. Learn more here!

Protein type aa

How much do you know about protein type aa? This condition is also known as amyloidosis and involves a protein buildup in the vital organs. The number of different proteins in the human body varies based on how they’re defined.

In 2014 a German research team discovered 86,771 proteins in the human body. Proteins are one of the three macronutrients found in the human body. It’s important to know about certain conditions like amyloidosis that involve problems related to a particular protein known as amyloids. You’ll want to know details like symptoms, causes, and treatments for amyloidosis so you can treat it effectively.

Amyloidosis involves a buildup of the protein in the patient’s vital organs. That, in turn, can cause the organs to malfunction, which is a situation you’ll certainly want to avoid. The disorder involves a “folding” disorder that’s important to deal with effectively. In normal situations, the body ditches/recycles proteins when it’s done using them. However, the situation is different with this protein disorder since it results in a buildup in a particular kind of protein in the body. You’ll also want to know about the different symptoms related to the stomach, liver, and heart.

What Exactly Is Amyloidosis?

This is a type of rare disease that happens when an abnormal protein known as an “amyloid” builds up within a vital organ so it stops functioning normally. In most cases, amyloids aren’t found in the human body. In more cases, it forms from many kinds of protein. This condition can affect various body parts:

  • Heart
  • Liver
  • Kidneys
  • Stomach
  • Brain

Sometimes amyloidosis is related to various other diseases. The types can improve by treating the main disease. However, when someone has a serious case of amyloidosis this can result in organ failure.

As with other protein-related conditions, it’s important to know the signs/symptoms of protein type aa. You’ll then know the signs that you’re experiencing the condition. This can result in an accurate diagnosis instead of being misdiagnosed. That’s a situation you’ll want to avoid.

The symptoms can affect different body parts. They include the stomach, liver, and heart. You might even experience different symptoms that involve these body parts. In some situations, the symptoms might be like those of other conditions. So if you suspect you might have amyloidosis you get it checked out.

One reason there are so many possible symptoms is there are several kinds of amyloidosis. They can be related to different factors like genetics, inflammation, diseases, and so on. Another factor is this condition can also affect different organs. Sometimes it affects one organ and other times it affects multiple organs.

There are also various risk factors to be aware of. They include age, gender, health conditions, and others. It’s critical to know about them.

There are also various treatments that patients can receive to treat the condition. They include prescription medications, chemotherapy, and organ/stem cell transplants. A doctor can help to determine which treatment would be the best option for your particular situation.

Protein Type AA: Symptoms and Causes

SYMPTOMS

This condition can affect various organs. That, in turn, can affect various body parts. They include:

  • Liver
    • Enlarged liver
  • Heart 
    • Racing heart
    • Chest pain
    • Leg/Feet swelling
  • Breathing problems
    • Stomach/Intestines 
    • Constipation
    • LBM
    • Bleeding
  • Other 
    • High protein in the urine
    • High cholesterol
    • Enlarged spleen

CAUSES

It’s important to note that there are several kinds of amyloidosis. Some kinds are hereditary, while others are caused by inflammation. Many kinds affect organs while others only affect one body part.

The different types are quite technical. So it’s best to learn the basics so you’ll be able to recognize if you have symptoms of certain kinds of amyloidosis. Then you can get the right treatment you need for the type you have.

There are also possible risk factors to know about:

  1. Age: People who are diagnosed with this condition are usually between 60 and 70 years old. However, it’s also possible to be diagnosed at a younger age.
  2. Gender: There are more men than women who are diagnosed with amyloidosis
  3. Kidney Dialysis: People with this treatment might have problems getting rid of big proteins in the blood. When this happens abnormal proteins can build up within the blood then get deposited into tissue. This happens more often when modern dialysis methods are used.
  4. Genetics: Certain kinds of amyloidosis are hereditary. So if your relatives have the condition there’s a greater chance you will as well.
  5. Other Diseases: People with an inflammatory disease or major infections are more likely to have AA amyloidosis.

Various possible complications can involve:

  • Kidneys
  • Heart
  • Nervous System

Amyloidosis: Diagnosis and Treatment

DIAGNOSIS

Patients with inflammation or other health conditions are more likely to be diagnosed with amyloidosis. The most common organ that’s affected is the kidney although others might be affected.

Your doctor might order a biopsy to check if you have AA amyloidosis. One of the first areas that are checked is stomach fat right under the skin. If the test is negative then there’s something known as a “fat pad biopsy” that’s sometimes ordered. If the result is negative then a biopsy is taken from the affected organ.

In the case the biopsy is positive the tissue sample then gets more testing. This is done to check another kind of amyloidosis known as “AL.” The main difference is this is a more aggressive kind of amyloidosis.

Besides biopsies, there are various other kinds of tests. They include:

  • Imaging Tests
  • Nuclear Imaging
  • Echocardiogram
  • MRI

TREATMENTS

Targeted Therapies

Certain medicines work with certain kinds of amyloidosis. It provides various benefits that can deal with certain symptoms. It’s important to talk to your doctor about the best one for your situation.

Heart Medicines

In the case the heart gets affected, the doctor could recommend blood thinners. It is used to lower the risk of blood clots. Medicines to control heart rate might also be prescribed. Patients might also have to lower salt intake and take medicines to boost urination. That can help to take the pressure off the kidneys/heart.

Procedures/Surgeries

There are various kinds of surgeries and procedures that your doctor might suggest for you. They include various ones like stem cell transplant, dialysis, and organ transplant. They’re different kinds of procedures, so it’s important to talk to your doctor about which one is best for your situation.

Chemotherapy

This type of treatment is quite similar to cancer treatments. Several of the medicines used are the same ones that are used to treat cancer. The goal is to stop abnormal cells growing that make the protein that leads to protein type aa.

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